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Lifelong platonic friends Zack (Rogen) and Miri (Banks) look to solve their cashflow problems by making an adult film together. But, they begin to sense that they may have more feelings for each other than they previously thought.

In the not too distant future a secret government re-animation chemo-virus gets released into conservative Sartre, Nebraska and lands in an underground strip club.

At the end of his career, a clueless fashion model is brainwashed to kill the Prime Minister of Malaysia.