American Guys is a slice of life comedy about four young roommates. Steve, Ray, Jim, and Benny are always behind on bills and after a big party they receive an eviction notice from their irate landlord Mr. Goss. Ray soon meets a lovely young woman named Stacy and her child Brandon who live across the street with her abusive finance' Mark. With Stacy now on Ray's mind he and Steve go on a camping trip to unwind and figure out what they are going to do. Their trip is cut short by a scary encounter with a family of hillbillies who chase them away. Ray's fondness for Stacy and Brandon grows and when Mark hurts her, he decides to protect them by letting them stay with him. More trouble comes for the guys when two nosey neighbors who have been spying on the house decide to call the FBI. When Mark is questioned by the authorities he says that they have kidnapped his wife and son. What happens if the guys get raided? How will they escape? What will become of the American Guys haven and their makeshift inventions such as a home homemade pool table and a hot tub built out of a refrigerator?