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When human forces discover the existence of the Vampire and Lycan clans, a war to eradicate both species commences. The vampire warrioress Selene leads the battle against humankind.

Underneath the city streets, amid the labyrinth of subway tunnels and gothic ruins, vampires and werewolves are embroiled in an all-out war that has been going on for centuries.

Story of a woman caught in a futuristic civil war between the government and a subculture of disease modified humans in whom speed, strength and intelligence are magnified.