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Steady diet of prescription drugs and sex opens an angst-ridden 17-year-old's eyes to one of life's little secrets: adults are just as messed up as teenagers.

Theater director Caden Cotard (Philip Seymour Hoffman) is mounting a new play. His life catering to suburban blue-hairs at the local regional theater in Schenectady, New York is looking bleak.

Jennifer Aniston, Catherine Keener, Frances McDormand and Joan Cusak play four best friends whose comfortable lives are thrown off-balance as the realities of early middle-age set in.