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A new comedy from the creative genius of Judd Apatow follows a pair of druggie losers as they reach the top of the hit-list when one witnesses a mob murder and drags his buddy into a crazy flight from mobsters bent on silencing both of them permanently.

Paul has lived in the same town all his life. He has a close group of friends but when he meets his friends' sister, who has just graduated from prep school, his life begins to change.