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When Joel (Fran Kranz) is publicly humiliated on national television by "Dr. Dwayne" (Darrell Hammond), he falls into a serious funk until his friends Wyatt (Kenan Thompson) and Ben (Zachary Levi) force him to join them on a cross-country road trip..

When a small-town sheriff (Larry the Cable Guy) witnesses what he believes to be an attempted kidnapping, his effort to save the beautiful damsel in distress sets him down a wild path of comic mishap.